› 1wco

Solution NMR

The solution structure of the nisin-lipid II complex

Released:
DOI: 10.2210/pdb1wco/pdb
PDB entry 1wco coloured by chain, ensemble of 20 models, front view.
PDB entry 1wco coloured by chain, ensemble of 20 models, side view.
PDB entry 1wco coloured by chain, ensemble of 20 models, top view.
Source organisms:
Primary publication:
The nisin-lipid II complex reveals a pyrophosphate cage that provides a blueprint for novel antibiotics.
Hsu ST, Breukink E, Tischenko E, Lutters MA, de Kruijff B, Kaptein R, Bonvin AM, van Nuland NA
Nat Struct Mol Biol 11 963-7 (2004)
PMID: 15361862

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domain:
Structure domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151538 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
ALA-FGA-LYS-DAL-DAL PEPTIDE Chain: L
Molecule details ›
Chain: L
Length: 5 amino acids
Theoretical weight: 490 Da
Source organism: Monarthropalpus flavus
Lantibiotic nisin-Z Chain: N
Molecule details ›
Chain: N
Length: 34 amino acids
Theoretical weight: 3.35 KDa
Source organism: Lactococcus lactis
UniProt:
  • Canonical: P29559 (Residues: 24-57; Coverage: 60%)
Gene name: nisZ
Sequence domains: Gallidermin

Ligands and Environments

Carbohydrate polymer : NEW Components: MUB, NAG
Carbohydrate polymer
1 bound ligand:
Ligand FDF 1 x FDF
5 modified residues:
Ligand FGA 1 x FGA
Ligand DAL 3 x DAL
Ligand DBU 1 x DBU
Ligand DHA 2 x DHA
Ligand DBB 4 x DBB

Experiments and Validation Details

Entry percentile scores
Refinement method: HADDOCK

Quick links

Citations

92 review citations

Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies.
Hancock et al. (2006)
91 more

29 mentions without citation

Antibiotics from microbes: converging to kill.
Fischbach MA. (2009)
28 more