› 1wms

X-ray diffraction
1.25Å resolution

High resolution crystal structure of human Rab9 GTPase: a novel antiviral drug target

Released:
DOI: 10.2210/pdb1wms/pdb
PDB entry 1wms coloured by chain, front view.
PDB entry 1wms coloured by chain, side view.
PDB entry 1wms coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
High resolution crystal structure of human Rab9 GTPase: a novel antiviral drug target.
Chen L, DiGiammarino E, Zhou XE, Wang Y, Toh D, Hodge TW, Meehan EJ
J Biol Chem 279 40204-8 (2004)
PMID: 15263003

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156310 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ras-related protein Rab-9A Chains: A, B
Molecule details ›
Chains: A, B
Length: 177 amino acids
Theoretical weight: 20.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P51151 (Residues: 1-177; Coverage: 88%)
Gene names: RAB9, RAB9A
Sequence domains: Ras family
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

1 bound ligand:
Ligand GDP 2 x GDP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P1
Unit cell:
a: 38.4Å b: 45.62Å c: 51.22Å
α: 99.75° β: 107.17° γ: 101.84°
R-values:
R R work R free
0.141 0.139 0.196
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

Structural clues to Rab GTPase functional diversity.
Pfeffer SR. (2005)
3 other articles

6 mentions without citation

Predicting new indications for approved drugs using a proteochemometric method.
Dakshanamurthy et al. (2012)
5 more