› 1wrk

X-ray diffraction
2.15Å resolution

Crystal structure of the N-terminal domain of human cardiac troponin C in complex with trifluoperazine (orthrombic crystal form)

Released:
DOI: 10.2210/pdb1wrk/pdb
PDB entry 1wrk coloured by chain, front view.
PDB entry 1wrk coloured by chain, side view.
PDB entry 1wrk coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Takeda S, Igarashi T, Oishi Y, Mori H

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159089 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Troponin C, slow skeletal and cardiac muscles Chains: A, B
Molecule details ›
Chains: A, B
Length: 88 amino acids
Theoretical weight: 9.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P63316 (Residues: 1-88; Coverage: 55%)
Gene names: TNNC, TNNC1
Sequence domains: EF-hand domain pair
Structure domains: EF-hand

Ligands and Environments

2 bound ligands:
Ligand CA 2 x CA
Ligand TFP 4 x TFP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL45PX
Spacegroup: P212121
Unit cell:
a: 40.33Å b: 47.9Å c: 98.64Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.231 0.23 0.251
Expression system: Escherichia coli

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