› 1wsx

Solution NMR

Solution structure of MCL-1

Released:
DOI: 10.2210/pdb1wsx/pdb
PDB entry 1wsx coloured by chain, ensemble of 20 models, front view.
PDB entry 1wsx coloured by chain, ensemble of 20 models, side view.
PDB entry 1wsx coloured by chain, ensemble of 20 models, top view.
Source organism: Mus musculus
Primary publication:
Solution structure of prosurvival Mcl-1 and characterization of its binding by proapoptotic BH3-only ligands.
Day CL, Chen L, Richardson SJ, Harrison PJ, Huang DC, Hinds MG
J Biol Chem 280 4738-44 (2005)
PMID: 15550399

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161280 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Induced myeloid leukemia cell differentiation protein Mcl-1 homolog Chain: A
Molecule details ›
Chain: A
Length: 162 amino acids
Theoretical weight: 18.26 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P97287 (Residues: 152-308; Coverage: 47%)
Gene name: Mcl1
Sequence domains: Apoptosis regulator proteins, Bcl-2 family
Structure domains: Blc2-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics, distance geometry, simulated annealing
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

34 review citations

The BCL-2 protein family: opposing activities that mediate cell death.
Youle et al. (2008)
33 more

11 mentions without citation

The Structural Biology of Bcl-xL.
Lee et al. (2019)
10 more