› 1x8y

X-ray diffraction
2.2Å resolution

Human lamin coil 2B

Released:
DOI: 10.2210/pdb1x8y/pdb
PDB entry 1x8y coloured by chain, front view.
PDB entry 1x8y coloured by chain, side view.
PDB entry 1x8y coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the human lamin A coil 2B dimer: implications for the head-to-tail association of nuclear lamins.
Strelkov SV, Schumacher J, Burkhard P, Aebi U, Herrmann H
J Mol Biol 343 1067-80 (2004)
PMID: 15476822

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-135893 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lamin-A/C Chain: A
Molecule details ›
Chain: A
Length: 86 amino acids
Theoretical weight: 10.19 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P02545 (Residues: 305-387; Coverage: 13%)
Gene names: LMN1, LMNA
Structure domains: Single alpha-helices involved in coiled-coils or other helix-helix interfaces

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P6522
Unit cell:
a: 89.267Å b: 89.267Å c: 75.589Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.276 0.274 0.305
Expression system: Escherichia coli

Quick links

Citations

34 review citations

Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin.
Dechat et al. (2008)
33 more

10 mentions without citation

The lamin protein family.
Dittmer et al. (2011)
9 more