› 1xfb

X-ray diffraction
3Å resolution

Human Brain Fructose 1,6-(bis)phosphate Aldolase (C isozyme)

Released:
DOI: 10.2210/pdb1xfb/pdb
PDB entry 1xfb coloured by chain, front view.
PDB entry 1xfb coloured by chain, side view.
PDB entry 1xfb coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of human brain fructose 1,6-(bis)phosphate aldolase: linking isozyme structure with function.
Arakaki TL, Pezza JA, Cronin MA, Hopkins CE, Zimmer DB, Tolan DR, Allen KN
Protein Sci 13 3077-84 (2004)
PMID: 15537755

Function and Biology Details

Reaction catalysed: 
D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140871 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fructose-bisphosphate aldolase C Chains: A, B, C, D, E, F, G, H, I, J, K, L
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L
Length: 365 amino acids
Theoretical weight: 39.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P09972 (Residues: 1-364; Coverage: 100%)
Gene names: ALDC, ALDOC
Sequence domains: Fructose-bisphosphate aldolase class-I
Structure domains: Aldolase class I

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: P1
Unit cell:
a: 83.872Å b: 121.986Å c: 129.517Å
α: 107.96° β: 108.58° γ: 97.39°
R-values:
R R work R free
0.257 0.255 0.261
Expression system: Escherichia coli

Quick links

Citations

6 review citations

The Cerebellum: Adaptive Prediction for Movement and Cognition.
Sokolov et al. (2017)
5 more

5 mentions without citation

Structure of human brain fructose 1,6-(bis)phosphate aldolase: linking isozyme structure with function.
Arakaki et al. (2004)
4 more