› 1xg5

X-ray diffraction
1.53Å resolution

Structure of human putative dehydrogenase MGC4172 in complex with NADP

Released:
DOI: 10.2210/pdb1xg5/pdb
PDB entry 1xg5 coloured by chain, front view.
PDB entry 1xg5 coloured by chain, side view.
PDB entry 1xg5 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Kavanagh K, Ng S, Sharma S, Vedadi M, von Delft F, Walker JR, dhe Paganon S, Bray J, Oppermann U, Edwards A, Arrowsmith C, Sundstrom M, Structural Genomics Consortium (SGC)

Function and Biology Details

Reactions catalysed: 
A 3-beta-hydroxysteroid + NADP(+) = a 3-oxosteroid + NADPH
17-beta-estradiol + NAD(P)(+) = estrone + NAD(P)H
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180420 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dehydrogenase/reductase SDR family member 11 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 279 amino acids
Theoretical weight: 30.47 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q6UWP2 (Residues: 1-256; Coverage: 98%)
Gene names: DHRS11, SDR24C1, UNQ836/PRO1774
Sequence domains: short chain dehydrogenase
Structure domains: NAD(P)-binding Rossmann-like Domain

Ligands and Environments


Cofactor: Ligand NAP 4 x NAP
1 bound ligand:
Ligand ACY 3 x ACY
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P21
Unit cell:
a: 54.71Å b: 124.669Å c: 75.13Å
α: 90° β: 97.23° γ: 90°
R-values:
R R work R free
0.162 0.162 0.206
Expression system: Escherichia coli

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