› 1xk4

X-ray diffraction
1.8Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138505 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Protein S100-A8 Chains: A, B, E, F, I, J
Molecule details ›
Chains: A, B, E, F, I, J
Length: 93 amino acids
Theoretical weight: 10.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P05109 (Residues: 1-93; Coverage: 100%)
Gene names: CAGA, CFAG, MRP8, S100A8
Sequence domains: S-100/ICaBP type calcium binding domain
Structure domains: EF-hand
Protein S100-A9 Chains: C, D, G, H, K, L
Molecule details ›
Chains: C, D, G, H, K, L
Length: 113 amino acids
Theoretical weight: 13.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P06702 (Residues: 2-114; Coverage: 99%)
Gene names: CAGB, CFAG, MRP14, S100A9
Sequence domains: S-100/ICaBP type calcium binding domain
Structure domains: EF-hand

Ligands and Environments

3 bound ligands:
Ligand CA 24 x CA
Ligand CL 4 x CL
Ligand FLC 1 x FLC
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P21
Unit cell:
a: 48.509Å b: 78.697Å c: 177.411Å
α: 90° β: 94.94° γ: 90°
R-values:
R R work R free
0.16 0.158 0.205
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

45 review citations

Functions of S100 proteins.
Donato et al. (2013)
44 more

30 mentions without citation

Transition Metal Sequestration by the Host-Defense Protein Calprotectin.
Zygiel et al. (2018)
29 more