› 1xmi

X-ray diffraction
2.25Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
homo pentamer (preferred)
homo decamer
Assembly name:
PDBe Complex ID:
PDB-CPX-146661 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cystic fibrosis transmembrane conductance regulator Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 291 amino acids
Theoretical weight: 32.48 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P13569 (Residues: 388-678; Coverage: 20%)
Gene names: ABCC7, CFTR
Sequence domains: ABC transporter
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

2 bound ligands:
Ligand MG 5 x MG
Ligand ATP 5 x ATP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 31-ID
Spacegroup: C2221
Unit cell:
a: 144.461Å b: 154.022Å c: 136.088Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.232 0.212 0.265
Expression system: Escherichia coli

Quick links

Citations

45 review citations

Transmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins.
Deeley et al. (2006)
44 more

20 mentions without citation

Cystic fibrosis lung environment and Pseudomonas aeruginosa infection.
Bhagirath et al. (2016)
19 more