› 1xnx

X-ray diffraction
2.9Å resolution

Crystal structure of constitutive androstane receptor

Released:
DOI: 10.2210/pdb1xnx/pdb
PDB entry 1xnx coloured by chain, front view.
PDB entry 1xnx coloured by chain, side view.
PDB entry 1xnx coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structure of the murine constitutive androstane receptor complexed to androstenol: a molecular basis for inverse agonism.
Shan L, Vincent J, Brunzelle JS, Dussault I, Lin M, Ianculescu I, Sherman MA, Forman BM, Fernandez EJ
Mol Cell 16 907-17 (2004)
PMID: 15610734

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-128699 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nuclear receptor subfamily 1 group I member 3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 256 amino acids
Theoretical weight: 29.65 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: O35627 (Residues: 109-358; Coverage: 70%)
Gene names: Car, Nr1i3
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
Ligand ATE 2 x ATE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 5ID-B
Spacegroup: C2221
Unit cell:
a: 60.353Å b: 155.042Å c: 134.607Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.229 0.229 0.288
Expression system: Escherichia coli

Quick links

Citations

35 review citations

Inhibition and induction of human cytochrome P450 enzymes: current status.
Pelkonen et al. (2008)
34 more

10 mentions without citation

Small-molecule modulators of PXR and CAR.
Chai et al. (2016)
9 more