› 1xph

X-ray diffraction
1.41Å resolution

Structure of DC-SIGNR and a portion of repeat domain 8

Released:
DOI: 10.2210/pdb1xph/pdb
PDB entry 1xph coloured by chain, front view.
PDB entry 1xph coloured by chain, side view.
PDB entry 1xph coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structure of DC-SIGNR with a portion of its repeat domain lends insights to modeling of the receptor tetramer.
Snyder GA, Colonna M, Sun PD
J Mol Biol 347 979-89 (2005)
PMID: 15784257

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190558 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
C-type lectin domain family 4 member M Chain: A
Molecule details ›
Chain: A
Length: 150 amino acids
Theoretical weight: 17.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9H2X3 (Residues: 250-399; Coverage: 38%)
Gene names: CD209L, CD209L1, CD299, CLEC4M
Sequence domains: Lectin C-type domain
Structure domains: Mannose-Binding Protein A, subunit A

Ligands and Environments

1 bound ligand:
Ligand CA 1 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P212121
Unit cell:
a: 38.233Å b: 54.887Å c: 62.352Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.177 0.176 0.193
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 review citations

DC-SIGN and L-SIGN: the SIGNs for infection.
Khoo et al. (2008)
1 more

11 mentions without citation

Human cell receptors: potential drug targets to combat COVID-19.
Raghav et al. (2021)
10 more