› 1xqr

X-ray diffraction
2.1Å resolution

Crystal structure of the HspBP1 core domain

Released:
DOI: 10.2210/pdb1xqr/pdb
PDB entry 1xqr coloured by chain, front view.
PDB entry 1xqr coloured by chain, side view.
PDB entry 1xqr coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Regulation of Hsp70 function by HspBP1: structural analysis reveals an alternate mechanism for Hsp70 nucleotide exchange.
Shomura Y, Dragovic Z, Chang HC, Tzvetkov N, Young JC, Brodsky JL, Guerriero V, Hartl FU, Bracher A
Mol Cell 17 367-79 (2005)
PMID: 15694338

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192762 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hsp70-binding protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 296 amino acids
Theoretical weight: 33.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NZL4 (Residues: 84-359; Coverage: 77%)
Gene names: HSPBP, HSPBP1, PP1845
Sequence domains: Nucleotide exchange factor Fes1
Structure domains: Leucine-rich Repeat Variant

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 20 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: C2
Unit cell:
a: 76.68Å b: 84.286Å c: 89.945Å
α: 90° β: 96° γ: 90°
R-values:
R R work R free
0.213 0.211 0.249
Expression system: Escherichia coli

Quick links

Citations

31 review citations

Molecular chaperones and protein quality control.
Bukau et al. (2006)
30 more

10 mentions without citation

Gating machinery of InsP3R channels revealed by electron cryomicroscopy.
Fan et al. (2015)
9 more