› 1xtb

X-ray diffraction
2Å resolution

Crystal Structure of Rabbit Phosphoglucose Isomerase Complexed with Sorbitol-6-Phosphate

Released:
DOI: 10.2210/pdb1xtb/pdb
PDB entry 1xtb coloured by chain, front view.
PDB entry 1xtb coloured by chain, side view.
PDB entry 1xtb coloured by chain, top view.
Source organism: Oryctolagus cuniculus
Primary publication:
The crystal structure of rabbit phosphoglucose isomerase complexed with D-sorbitol-6-phosphate, an analog of the open chain form of D-glucose-6-phosphate.
Lee JH, Jeffery CJ
Protein Sci 14 727-34 (2005)
PMID: 15689508

Function and Biology Details

Reaction catalysed: 
Alpha-D-glucose 6-phosphate = beta-D-fructofuranose 6-phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192403 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glucose-6-phosphate isomerase Chains: A, B
Molecule details ›
Chains: A, B
Length: 558 amino acids
Theoretical weight: 62.83 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: Q9N1E2 (Residues: 1-558; Coverage: 100%)
Gene name: GPI
Sequence domains: Phosphoglucose isomerase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand S6P 2 x S6P
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: C2221
Unit cell:
a: 82.77Å b: 115.19Å c: 271.79Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.201 0.199 0.219

Quick links

Citations

9 citation in other articles

Prediction of distal residue participation in enzyme catalysis.
Brodkin et al. (2015)
8 more

4 mentions without citation

Post-duplication charge evolution of phosphoglucose isomerases in teleost fishes through weak selection on many amino acid sites.
Sato et al. (2007)
3 more