› 1xw6

X-ray diffraction
1.9Å resolution

1.9 angstrom resolution structure of human glutathione S-transferase M1A-1A complexed with glutathione

Released:
DOI: 10.2210/pdb1xw6/pdb
PDB entry 1xw6 coloured by chain, front view.
PDB entry 1xw6 coloured by chain, side view.
PDB entry 1xw6 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Transition state model and mechanism of nucleophilic aromatic substitution reactions catalyzed by human glutathione S-transferase M1a-1a.
Patskovsky Y, Patskovska L, Almo SC, Listowsky I
Biochemistry 45 3852-62 (2006)
PMID: 16548513

Function and Biology Details

Reaction catalysed: 
RX + glutathione = HX + R-S-glutathione
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140674 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutathione S-transferase Mu 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 218 amino acids
Theoretical weight: 25.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P09488 (Residues: 1-218; Coverage: 100%)
Gene names: GST1, GSTM1
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand GSH 4 x GSH
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P212121
Unit cell:
a: 55.97Å b: 84.38Å c: 212.18Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.24 0.227 0.247
Expression system: Escherichia coli BL21(DE3)

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Citations

3 review citations

Glutathione transferases, regulators of cellular metabolism and physiology.
Board et al. (2013)
2 more

6 mentions without citation

Prediction of substrates for glutathione transferases by covalent docking.
Dong et al. (2014)
5 more