› 1y08

X-ray diffraction
1.93Å resolution

Structure of the Streptococcal Endopeptidase IdeS, a Novel Cysteine Proteinase with Strict Specificity for IgG

Released:
DOI: 10.2210/pdb1y08/pdb
PDB entry 1y08 coloured by chain, front view.
PDB entry 1y08 coloured by chain, side view.
PDB entry 1y08 coloured by chain, top view.
Source organism: Streptococcus pyogenes
Primary publication:
Structure of the streptococcal endopeptidase IdeS, a cysteine proteinase with strict specificity for IgG.
Wenig K, Chatwell L, von Pawel-Rammingen U, Björck L, Huber R, Sondermann P
Proc Natl Acad Sci U S A 101 17371-6 (2004)
PMID: 15574492

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190238 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ig protease IdeS domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 323 amino acids
Theoretical weight: 36.39 KDa
Source organism: Streptococcus pyogenes
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9F1R7 (Residues: 34-339; Coverage: 90%)
Gene name: sib38
Sequence domains: Mac 1
Structure domains: Cysteine proteinases

Ligands and Environments

1 bound ligand:
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MPG/DESY, HAMBURG BEAMLINE BW6
Spacegroup: P21212
Unit cell:
a: 63.371Å b: 86.829Å c: 57.664Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.196 0.196 0.235
Expression system: Escherichia coli

Quick links

Citations

14 review citations

SCA3: neurological features, pathogenesis and animal models.
Riess et al. (2008)
13 more

2 mentions without citation

Structure of the streptococcal endopeptidase IdeS, a cysteine proteinase with strict specificity for IgG.
Wenig et al. (2004)
1 more