1y6m

X-ray diffraction
2.8Å resolution

Crystal structure of Epstein-Barr virus IL-10 complexed with the soluble IL-10R1 chain

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-136628 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Viral interleukin-10 homolog Chain: L
Molecule details ›
Chain: L
Length: 145 amino acids
Theoretical weight: 17.16 KDa
Source organism: human gammaherpesvirus 4
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P03180 (Residues: 26-170; Coverage: 99%)
Gene name: BCRF1
Sequence domains: Interleukin 10
Structure domains: Growth Hormone; Chain: A;
Interleukin-10 receptor subunit alpha Chain: R
Molecule details ›
Chain: R
Length: 214 amino acids
Theoretical weight: 24.51 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: Q13651 (Residues: 22-235; Coverage: 38%)
Gene names: IL10R, IL10RA
Sequence domains: Tissue factor
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-2
Spacegroup: P3212
Unit cell:
a: 47.121Å b: 47.121Å c: 300.708Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.264 0.261 0.315
Expression systems:
  • Escherichia coli BL21(DE3)
  • Drosophila melanogaster