› 1yb5

X-ray diffraction
1.85Å resolution

Crystal structure of human Zeta-Crystallin with bound NADP

Released:
DOI: 10.2210/pdb1yb5/pdb
PDB entry 1yb5 coloured by chain, front view.
PDB entry 1yb5 coloured by chain, side view.
PDB entry 1yb5 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Debreczeni J, Berridge G, Kavanagh K, Colbrook S, Bray J, Williams L, Oppermann U, Sundstrom M, Arrowsmith C, Edwards A, Gileadi O, von Delft F, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
NADPH + 2 quinone = NADP(+) + 2 semiquinone
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-170623 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Quinone oxidoreductase Chains: A, B
Molecule details ›
Chains: A, B
Length: 351 amino acids
Theoretical weight: 37.81 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q08257 (Residues: 1-329; Coverage: 100%)
Gene name: CRYZ
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand NAP 2 x NAP
3 bound ligands:
Ligand ACT 3 x ACT
Ligand CL 4 x CL
Ligand GOL 4 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E
Spacegroup: P21212
Unit cell:
a: 99.484Å b: 110.239Å c: 77.253Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.171 0.17 0.207
Expression system: Escherichia coli

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