› 1ycs

X-ray diffraction
2.2Å resolution

P53-53BP2 COMPLEX

Released:
DOI: 10.2210/pdb1ycs/pdb
PDB entry 1ycs coloured by chain, front view.
PDB entry 1ycs coloured by chain, side view.
PDB entry 1ycs coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2.
Gorina S, Pavletich NP
Science 274 1001-5 (1996)
PMID: 8875926

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138119 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Cellular tumor antigen p53 Chain: A
Molecule details ›
Chain: A
Length: 199 amino acids
Theoretical weight: 22.45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04637 (Residues: 94-292; Coverage: 51%)
Gene names: P53, TP53
Sequence domains: P53 DNA-binding domain
Structure domains: Immunoglobulin-like
Apoptosis-stimulating of p53 protein 2 Chain: B
Molecule details ›
Chain: B
Length: 239 amino acids
Theoretical weight: 26.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13625 (Residues: 892-925, 926-1128; Coverage: 21%)
Gene names: ASPP2, BBP, TP53BP2
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1
Spacegroup: P212121
Unit cell:
a: 68.8Å b: 72.8Å c: 119Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.205 0.205 0.286
Expression system: Escherichia coli

Quick links

Citations

69 review citations

The p53 pathway.
Prives et al. (1999)
68 more

53 mentions without citation

Classification of intrinsically disordered regions and proteins.
van der Lee et al. (2014)
52 more