› 1yh3

X-ray diffraction
1.91Å resolution

Crystal structure of human CD38 extracellular domain

Released:
DOI: 10.2210/pdb1yh3/pdb
PDB entry 1yh3 coloured by chain, front view.
PDB entry 1yh3 coloured by chain, side view.
PDB entry 1yh3 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of human CD38 extracellular domain.
Liu Q, Kriksunov IA, Graeff R, Munshi C, Lee HC, Hao Q
Structure 13 1331-9 (2005)
PMID: 16154090

Function and Biology Details

Reactions catalysed: 
(1a) NADP(+) = 2'-phospho-cyclic ADP-ribose + nicotinamide
(1a) NAD(+) = cyclic ADP-ribose + nicotinamide
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151306 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 256 amino acids
Theoretical weight: 29.65 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P28907 (Residues: 45-300; Coverage: 85%)
Gene name: CD38
Sequence domains: ADP-ribosyl cyclase
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F1
Spacegroup: P1
Unit cell:
a: 41.839Å b: 51.491Å c: 66.439Å
α: 108.27° β: 90.47° γ: 97.29°
R-values:
R R work R free
0.192 0.188 0.253
Expression system: Komagataella pastoris

Quick links

Citations

33 review citations

Evolution and function of the ADP ribosyl cyclase/CD38 gene family in physiology and pathology.
Malavasi et al. (2008)
32 more

15 mentions without citation

Resolving the topological enigma in Ca2+ signaling by cyclic ADP-ribose and NAADP.
Lee et al. (2019)
14 more