› 1yi6

X-ray diffraction
2Å resolution

C-term tail segment of human tyrosine kinase (258-533)

Released:
DOI: 10.2210/pdb1yi6/pdb
PDB entry 1yi6 coloured by chain, front view.
PDB entry 1yi6 coloured by chain, side view.
PDB entry 1yi6 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Fleury D, Sarubbi E, Courjaud A, Guitton JD, Ducruix A

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146379 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Proto-oncogene tyrosine-protein kinase Src Chains: A, B
Molecule details ›
Chains: A, B
Length: 276 amino acids
Theoretical weight: 31.82 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P12931 (Residues: 261-536; Coverage: 52%)
Gene names: SRC, SRC1
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

No bound ligands
1 modified residue:
Ligand PTR 4 x PTR

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P21
Unit cell:
a: 66.985Å b: 63.421Å c: 76.693Å
α: 90° β: 109.54° γ: 90°
R-values:
R R work R free
0.226 0.216 0.252
Expression system: Spodoptera frugiperda

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