› 1yiz

X-ray diffraction
1.55Å resolution

Aedes aegypti kynurenine aminotrasferase

Released:
DOI: 10.2210/pdb1yiz/pdb
PDB entry 1yiz coloured by chain, front view.
PDB entry 1yiz coloured by chain, side view.
PDB entry 1yiz coloured by chain, top view.
Source organism: Aedes aegypti
Primary publication:
Crystal structures of Aedes aegypti kynurenine aminotransferase.
Han Q, Gao YG, Robinson H, Ding H, Wilson S, Li J
FEBS J 272 2198-206 (2005)
PMID: 15853804

Function and Biology Details

Reactions catalysed: 
(1a) L-kynurenine + glyoxylate = 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine 
(1a) L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172640 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Kynurenine aminotransferase Chains: A, B
Molecule details ›
Chains: A, B
Length: 429 amino acids
Theoretical weight: 48.56 KDa
Source organism: Aedes aegypti
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q17CS8 (Residues: 49-477; Coverage: 90%)
Gene names: AAEL004435, KAT
Sequence domains: Aminotransferase class I and II
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand BR 5 x BR
1 modified residue:
Ligand LLP 2 x LLP

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X12C
Spacegroup: P212121
Unit cell:
a: 55.288Å b: 94.984Å c: 167.599Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.254 0.254 not available
Expression system: Spodoptera frugiperda

Quick links

Citations

3 review citations

Structure, expression, and function of kynurenine aminotransferases in human and rodent brains.
Han et al. (2010)
2 more

3 mentions without citation

Detect, correct, retract: How to manage incorrect structural models.
Wlodawer et al. (2018)
2 more