1yk0

X-ray diffraction
2.4Å resolution

structure of natriuretic peptide receptor-C complexed with atrial natriuretic peptide

Released:
Source organism: Homo sapiens

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-134080 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Atrial natriuretic peptide receptor 3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 480 amino acids
Theoretical weight: 52.9 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: P17342 (Residues: 1-480; Coverage: 88%)
Gene names: ANPRC, C5orf23, NPR3, NPRC
Sequence domains: Receptor family ligand binding region
Structure domains: Rossmann fold
Atriopeptin-1 Chain: E
Molecule details ›
Chain: E
Length: 21 amino acids
Theoretical weight: 2.17 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01160 (Residues: 129-149; Coverage: 17%)
Gene names: ANP, NPPA, PND
Sequence domains: Atrial natriuretic peptide

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL11-1
Spacegroup: P212121
Unit cell:
a: 56.866Å b: 135.468Å c: 137.698Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.242 0.24 0.284
Expression systems:
  • Drosophila melanogaster
  • Not provided