1yk1

X-ray diffraction
2.9Å resolution

structure of natriuretic peptide receptor-C complexed with brain natriuretic peptide

Released:
Source organism: Homo sapiens

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-147821 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Atrial natriuretic peptide receptor 3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 479 amino acids
Theoretical weight: 52.77 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: P17342 (Residues: 2-480; Coverage: 88%)
Gene names: ANPRC, C5orf23, NPR3, NPRC
Sequence domains: Receptor family ligand binding region
Structure domains: Rossmann fold
BNP(4-27) Chain: E
Molecule details ›
Chain: E
Length: 21 amino acids
Theoretical weight: 2.21 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P16860 (Residues: 111-131; Coverage: 19%)
Gene name: NPPB
Sequence domains: Atrial natriuretic peptide

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL11-1
Spacegroup: P212121
Unit cell:
a: 56.174Å b: 136.38Å c: 138.693Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.254 0.253 0.289
Expression systems:
  • Drosophila melanogaster
  • Not provided