› 1ym3

X-ray diffraction
1.75Å resolution

Crystal Structure of carbonic anhydrase RV3588c from Mycobacterium tuberculosis

Released:
DOI: 10.2210/pdb1ym3/pdb
PDB entry 1ym3 coloured by chain, front view.
PDB entry 1ym3 coloured by chain, side view.
PDB entry 1ym3 coloured by chain, top view.
Source organism: Mycobacterium tuberculosis H37Rv
Primary publication:
Structure and function of carbonic anhydrases from Mycobacterium tuberculosis.
Suarez Covarrubias A, Larsson AM, Högbom M, Lindberg J, Bergfors T, Björkelid C, Mowbray SL, Unge T, Jones TA
J Biol Chem 280 18782-9 (2005)
PMID: 15753099

Function and Biology Details

Reaction catalysed: 
H(2)CO(3) = CO(2) + H(2)O
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161989 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Carbonic anhydrase 2 Chain: A
Molecule details ›
Chain: A
Length: 215 amino acids
Theoretical weight: 22.77 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Escherichia coli
UniProt:
  • Canonical: P9WPJ9 (Residues: 2-207; Coverage: 100%)
Gene names: Rv3588c, canB, cynT, mtcA2
Sequence domains: Carbonic anhydrase
Structure domains: Carbonic anhydrase

Ligands and Environments

2 bound ligands:
Ligand ZN 1 x ZN
Ligand MG 1 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MAX II BEAMLINE I711
Spacegroup: P41212
Unit cell:
a: 56.377Å b: 56.377Å c: 104.192Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.181 0.179 0.229
Expression system: Escherichia coli

Quick links

Citations

13 review citations

Carbonic anhydrases: novel therapeutic applications for inhibitors and activators.
Supuran CT. (2008)
12 more

6 mentions without citation

Mycobacterium tuberculosisβ-Carbonic Anhydrases: Novel Targets for Developing Antituberculosis Drugs.
Aspatwar et al. (2019)
5 more