› 1ypq

X-ray diffraction
1.4Å resolution

Human Oxidized Low Density Lipoprotein Receptor LOX-1 Dioxane Complex

Released:
DOI: 10.2210/pdb1ypq/pdb
PDB entry 1ypq coloured by chain, front view.
PDB entry 1ypq coloured by chain, side view.
PDB entry 1ypq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The 1.4 angstrom crystal structure of the human oxidized low density lipoprotein receptor lox-1.
Park H, Adsit FG, Boyington JC
J Biol Chem 280 13593-9 (2005)
PMID: 15695803

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160260 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Oxidized low-density lipoprotein receptor 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 135 amino acids
Theoretical weight: 15.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P78380 (Residues: 136-270; Coverage: 50%)
Gene names: CLEC8A, LOX1, OLR1
Sequence domains: Lectin C-type domain
Structure domains: Mannose-Binding Protein A, subunit A

Ligands and Environments

1 bound ligand:
Ligand DIO 1 x DIO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: C2
Unit cell:
a: 70.7Å b: 49.1Å c: 76.3Å
α: 90° β: 98.5° γ: 90°
R-values:
R R work R free
0.177 0.177 0.192
Expression system: Escherichia coli

Quick links

Citations

7 review citations

Scavenger receptors in homeostasis and immunity.
Canton et al. (2013)
6 more

10 mentions without citation

Functional analysis and molecular dynamics simulation of LOX-1 K167N polymorphism reveal alteration of receptor activity.
Biocca et al. (2009)
9 more