› 1yxb

X-ray diffraction
2.6Å resolution

Crystal structure of Phosphoribosyl-ATP pyrophosphatase from Streptomyces coelicolor. NESG target RR8.

Released:
DOI: 10.2210/pdb1yxb/pdb
PDB entry 1yxb coloured by chain, front view.
PDB entry 1yxb coloured by chain, side view.
PDB entry 1yxb coloured by chain, top view.
Source organism: Streptomyces coelicolor
Entry authors: Benach J, Kuzin AP, Forouhar F, Abashidze M, Vorobiev SM, Rong X, Acton TB, Montelione GT, Hunt JF, Northeast Structural Genomics Consortium (NESG)

Function and Biology Details

Reaction catalysed: 
1-(5-phospho-beta-D-ribosyl)-ATP + H(2)O = 1-(5-phospho-beta-D-ribosyl)-AMP + diphosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190214 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphoribosyl-ATP pyrophosphatase Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 98 amino acids
Theoretical weight: 11.19 KDa
Source organism: Streptomyces coelicolor
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9EWK0 (Residues: 1-90; Coverage: 100%)
Gene names: SC6D7A.02c, SCO1439, hisE
Sequence domains: Phosphoribosyl-ATP pyrophosphohydrolase
Structure domains: MazG-like

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 32 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P1
Unit cell:
a: 44.904Å b: 62.361Å c: 76.62Å
α: 79.21° β: 82.13° γ: 75.42°
R-values:
R R work R free
0.25 0.25 0.295
Expression system: Escherichia coli

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