› 1yz1

X-ray diffraction
2Å resolution

Crystal structure of human translationally controlled tumour associated protein

Released:
DOI: 10.2210/pdb1yz1/pdb
PDB entry 1yz1 coloured by chain, front view.
PDB entry 1yz1 coloured by chain, side view.
PDB entry 1yz1 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
TCTP protects from apoptotic cell death by antagonizing bax function.
Susini L, Besse S, Duflaut D, Lespagnol A, Beekman C, Fiucci G, Atkinson AR, Busso D, Poussin P, Marine JC, Martinou JC, Cavarelli J, Moras D, Amson R, Telerman A
Cell Death Differ 15 1211-20 (2008)
PMID: 18274553

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146705 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Translationally-controlled tumor protein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 174 amino acids
Theoretical weight: 19.9 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P13693 (Residues: 1-172; Coverage: 100%)
Gene name: TPT1
Sequence domains: Translationally controlled tumour protein
Structure domains: Metal Binding Protein, Guanine Nucleotide Exchange Factor; Chain A

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P21
Unit cell:
a: 63.853Å b: 93.674Å c: 70.349Å
α: 90° β: 114.86° γ: 90°
R-values:
R R work R free
0.191 0.191 0.238
Expression system: Escherichia coli

Quick links

Citations

12 review citations

The molecular programme of tumour reversion: the steps beyond malignant transformation.
Telerman et al. (2009)
11 more

15 mentions without citation

Histamine-releasing factor and immunoglobulins in asthma and allergy.
Kawakami et al. (2014)
14 more