› 1yzu

X-ray diffraction
2.5Å resolution

GppNHp-Bound Rab21 GTPase at 2.50 A Resolution

Released:
DOI: 10.2210/pdb1yzu/pdb
PDB entry 1yzu coloured by chain, front view.
PDB entry 1yzu coloured by chain, side view.
PDB entry 1yzu coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of family-wide Rab GTPase recognition by rabenosyn-5.
Eathiraj S, Pan X, Ritacco C, Lambright DG
Nature 436 415-9 (2005)
PMID: 16034420

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193906 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ras-related protein Rab-21 Chains: A, B
Molecule details ›
Chains: A, B
Length: 170 amino acids
Theoretical weight: 19.34 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UL25 (Residues: 16-183; Coverage: 75%)
Gene names: KIAA0118, RAB21
Sequence domains: Ras family
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

2 bound ligands:
Ligand MG 2 x MG
Ligand GNP 2 x GNP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: I212121
Unit cell:
a: 77.834Å b: 99.719Å c: 105.76Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.25 0.214 0.293
Expression system: Escherichia coli

Quick links

Citations

30 review citations

Rab GTPases as coordinators of vesicle traffic.
Stenmark H. (2009)
29 more

4 mentions without citation

Structural mechanisms for regulation of membrane traffic by rab GTPases.
Lee et al. (2009)
3 more