› 1z00

Solution NMR

Solution structure of the C-terminal domain of ERCC1 complexed with the C-terminal domain of XPF

Released:
DOI: 10.2210/pdb1z00/pdb
PDB entry 1z00 coloured by chain, ensemble of 20 models, front view.
PDB entry 1z00 coloured by chain, ensemble of 20 models, side view.
PDB entry 1z00 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
The structure of the human ERCC1/XPF interaction domains reveals a complementary role for the two proteins in nucleotide excision repair.
Tripsianes K, Folkers G, Ab E, Das D, Odijk H, Jaspers NG, Hoeijmakers JH, Kaptein R, Boelens R
Structure 13 1849-58 (2005)
PMID: 16338413

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139875 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
DNA excision repair protein ERCC-1 Chain: A
Molecule details ›
Chain: A
Length: 89 amino acids
Theoretical weight: 10 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P07992 (Residues: 220-297; Coverage: 26%)
Gene name: ERCC1
Sequence domains: Helix-hairpin-helix motif
Structure domains: 5' to 3' exonuclease, C-terminal subdomain
DNA repair endonuclease XPF Chain: B
Molecule details ›
Chain: B
Length: 84 amino acids
Theoretical weight: 9.23 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q92889 (Residues: 834-916; Coverage: 9%)
Gene names: ERCC11, ERCC4, XPF
Structure domains: 5' to 3' exonuclease, C-terminal subdomain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: water refinment in CNS
Expression system: Escherichia coli

Quick links

Citations

26 review citations

Structural and functional relationships of the XPF/MUS81 family of proteins.
Ciccia et al. (2008)
25 more

13 mentions without citation

XPA: A key scaffold for human nucleotide excision repair.
Sugitani et al. (2016)
12 more