› 1z40

X-ray diffraction
1.9Å resolution

AMA1 from Plasmodium falciparum

Released:
DOI: 10.2210/pdb1z40/pdb
PDB entry 1z40 coloured by chain, front view.
PDB entry 1z40 coloured by chain, side view.
PDB entry 1z40 coloured by chain, top view.
Source organism: Plasmodium falciparum 3D7
Primary publication:
Structure of AMA1 from Plasmodium falciparum reveals a clustering of polymorphisms that surround a conserved hydrophobic pocket.
Bai T, Becker M, Gupta A, Strike P, Murphy VJ, Anders RF, Batchelor AH
Proc Natl Acad Sci U S A 102 12736-41 (2005)
PMID: 16129835

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-181602 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Apical membrane antigen 1 Chains: A, E
Molecule details ›
Chains: A, E
Length: 336 amino acids
Theoretical weight: 38.42 KDa
Source organism: Plasmodium falciparum 3D7
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q7KQK5 (Residues: 104-438; Coverage: 56%)
Gene name: PF3D7_1133400
Sequence domains: Apical membrane antigen 1
Structure domains: Hepatocyte Growth Factor

Ligands and Environments

1 bound ligand:
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: P31
Unit cell:
a: 54.124Å b: 54.124Å c: 214.144Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.195 0.192 0.236
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

21 review citations

Invasion of red blood cells by malaria parasites.
Cowman et al. (2006)
20 more

23 mentions without citation

The Immune Epitope Database and Analysis Resource in Epitope Discovery and Synthetic Vaccine Design.
Fleri et al. (2017)
22 more