› 1z6c

Solution NMR

Solution structure of an EGF pair (EGF34) from vitamin K-dependent protein S

Released:
DOI: 10.2210/pdb1z6c/pdb
PDB entry 1z6c coloured by chain, ensemble of 20 models, front view.
PDB entry 1z6c coloured by chain, ensemble of 20 models, side view.
PDB entry 1z6c coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of the Ca2+-Binding EGF3-4 pair from vitamin K-dependent protein S: identification of an unusual fold in EGF3.
Drakenberg T, Ghasriani H, Thulin E, Thämlitz AM, Muranyi A, Annila A, Stenflo J
Biochemistry 44 8782-9 (2005)
PMID: 15952784

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139438 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Vitamin K-dependent protein S Chain: A
Molecule details ›
Chain: A
Length: 87 amino acids
Theoretical weight: 9.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P07225 (Residues: 200-286; Coverage: 13%)
Gene names: PROS, PROS1
Sequence domains: Calcium-binding EGF domain
Structure domains: Laminin

Ligands and Environments

1 bound ligand:
Ligand CA 2 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: Simulated annealing Torsion angle dynamics
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 review citations

Structures of thrombospondins.
Carlson et al. (2008)
2 more

2 mentions without citation

Protein C anticoagulant and cytoprotective pathways.
Griffin et al. (2012)
1 more