› 1z72

X-ray diffraction
1.45Å resolution

Structure of a putative transcriptional regulator from Streptococcus pneumoniae

Released:
DOI: 10.2210/pdb1z72/pdb
PDB entry 1z72 coloured by chain, front view.
PDB entry 1z72 coloured by chain, side view.
PDB entry 1z72 coloured by chain, top view.
Source organism: Streptococcus pneumoniae TIGR4
Entry authors: Cuff ME, Zhou M, Abdullah J, Joachimiak A, Midwest Center for Structural Genomics (MCSG)

Function and Biology Details

Reaction catalysed: 
4-amino-5-aminomethyl-2-methylpyrimidine + H(2)O = 4-amino-5-hydroxymethyl-2-methylpyrimidine + ammonia
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-101421 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Aminopyrimidine aminohydrolase Chains: A, B
Molecule details ›
Chains: A, B
Length: 225 amino acids
Theoretical weight: 26.1 KDa
Source organism: Streptococcus pneumoniae TIGR4
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: A0A0H2UP67 (Residues: 1-222; Coverage: 100%)
Gene name: SP_0716
Sequence domains: TENA/THI-4/PQQC family
Structure domains: Heme oxygenase-like

Ligands and Environments

2 bound ligands:
Ligand ACY 3 x ACY
Ligand MG 1 x MG
1 modified residue:
Ligand MSE 8 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P21212
Unit cell:
a: 116.023Å b: 122.039Å c: 46.48Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.152 0.151 0.167
Expression system: Escherichia coli BL21

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