› 1z83

X-ray diffraction
1.9Å resolution

Crystal structure of human AK1A in complex with AP5A

Released:
DOI: 10.2210/pdb1z83/pdb
PDB entry 1z83 coloured by chain, front view.
PDB entry 1z83 coloured by chain, side view.
PDB entry 1z83 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Filippakopoulos P, Bunkoczi G, Jansson A, Schreurs A, Knapp S, Edwards A, von Delft F, Sundstrom M, Structural Genomics Consortium (SGC)

Function and Biology Details

Reactions catalysed: 
NTP + AMP = NDP + ADP
ATP + AMP = 2 ADP
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
monomeric
Assembly name:
PDBe Complex ID:
PDB-CPX-132722 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Adenylate kinase isoenzyme 1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 196 amino acids
Theoretical weight: 21.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P00568 (Residues: 1-193; Coverage: 100%)
Gene name: AK1
Sequence domains: Adenylate kinase
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

3 bound ligands:
Ligand ZN 8 x ZN
Ligand SO4 3 x SO4
Ligand AP5 3 x AP5
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: C2
Unit cell:
a: 126.194Å b: 46.259Å c: 119.576Å
α: 90° β: 116.01° γ: 90°
R-values:
R R work R free
0.172 0.169 0.218
Expression system: Escherichia coli BL21(DE3)

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