› 1za4

X-ray diffraction
1.9Å resolution

Crystal Structure of the Thrombospondin-1 N-terminal Domain in Complex with Arixtra

Released:
DOI: 10.2210/pdb1za4/pdb
PDB entry 1za4 coloured by chain, front view.
PDB entry 1za4 coloured by chain, side view.
PDB entry 1za4 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structures of the thrombospondin-1 N-terminal domain and its complex with a synthetic pentameric heparin.
Tan K, Duquette M, Liu JH, Zhang R, Joachimiak A, Wang JH, Lawler J
Structure 14 33-42 (2006)
PMID: 16407063

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139878 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thrombospondin-1 Chain: A
Molecule details ›
Chain: A
Length: 251 amino acids
Theoretical weight: 27.65 KDa
Source organism: Homo sapiens
Expression system: Drosophila
UniProt:
  • Canonical: P07996 (Residues: 19-261; Coverage: 21%)
Gene names: THBS1, TSP, TSP1
Structure domains: Jelly Rolls

Ligands and Environments

2 bound ligands:
Ligand SGN 1 x SGN
Ligand SO4 5 x SO4
1 modified residue:
Ligand MSE 2 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P212121
Unit cell:
a: 42.404Å b: 53.053Å c: 92.723Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.271 0.245 0.275
Expression system: Drosophila

Quick links

Citations

9 review citations

The structure of glycosaminoglycans and their interactions with proteins.
Gandhi et al. (2008)
8 more

3 mentions without citation

The structures of the thrombospondin-1 N-terminal domain and its complex with a synthetic pentameric heparin.
Tan et al. (2006)
2 more