› 1zd2

X-ray diffraction
3Å resolution

Human soluble epoxide hydrolase 4-(3-cyclohexyluriedo)-ethanoic acid complex

Released:
DOI: 10.2210/pdb1zd2/pdb
PDB entry 1zd2 coloured by chain, front view.
PDB entry 1zd2 coloured by chain, side view.
PDB entry 1zd2 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Human soluble epoxide hydrolase: structural basis of inhibition by 4-(3-cyclohexylureido)-carboxylic acids.
Gomez GA, Morisseau C, Hammock BD, Christianson DW
Protein Sci 15 58-64 (2006)
PMID: 16322563

Function and Biology Details

Reactions catalysed: 
(9S,10S)-10-hydroxy-9-(phosphonooxy)octadecanoate + H(2)O = (9S,10S)-9,10-dihydroxyoctadecanoate + phosphate
An epoxide + H(2)O = a glycol
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152745 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bifunctional epoxide hydrolase 2 Chain: P
Molecule details ›
Chain: P
Length: 555 amino acids
Theoretical weight: 62.69 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P34913 (Residues: 1-555; Coverage: 100%)
Gene name: EPHX2
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand MG 1 x MG
Ligand PO4 1 x PO4
Ligand NC3 1 x NC3
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.3
Spacegroup: P6522
Unit cell:
a: 92.24Å b: 92.24Å c: 243.36Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.283 0.233 0.283
Expression system: Spodoptera frugiperda

Quick links

Citations

7 review citations

Discovery of inhibitors of soluble epoxide hydrolase: a target with multiple potential therapeutic indications.
Shen et al. (2012)
6 more

2 mentions without citation

Human soluble epoxide hydrolase: structural basis of inhibition by 4-(3-cyclohexylureido)-carboxylic acids.
Gomez et al. (2006)
1 more