› 1zdu

X-ray diffraction
2.5Å resolution

The Crystal Structure of Human Liver Receptor Homologue-1

Released:
DOI: 10.2210/pdb1zdu/pdb
PDB entry 1zdu coloured by chain, front view.
PDB entry 1zdu coloured by chain, side view.
PDB entry 1zdu coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The crystal structures of human steroidogenic factor-1 and liver receptor homologue-1.
Wang W, Zhang C, Marimuthu A, Krupka HI, Tabrizizad M, Shelloe R, Mehra U, Eng K, Nguyen H, Settachatgul C, Powell B, Milburn MV, West BL
Proc Natl Acad Sci U S A 102 7505-10 (2005)
PMID: 15897460

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126311 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Nuclear receptor subfamily 5 group A member 2 Chain: A
Molecule details ›
Chain: A
Length: 245 amino acids
Theoretical weight: 28.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O00482 (Residues: 297-541; Coverage: 45%)
Gene names: B1F, CPF, FTF, NR5A2
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
Nuclear receptor coactivator 2 Chains: P, Q
Molecule details ›
Chains: P, Q
Length: 11 amino acids
Theoretical weight: 1.35 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q15596 (Residues: 741-751; Coverage: 1%)
Gene names: BHLHE75, NCOA2, SRC2, TIF2

Ligands and Environments

2 bound ligands:
Ligand P3A 1 x P3A
Ligand TRS 1 x TRS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: P212121
Unit cell:
a: 61.01Å b: 67Å c: 78.21Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.242 0.239 0.281
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

25 review citations

Estrogen signaling through the transmembrane G protein-coupled receptor GPR30.
Prossnitz et al. (2008)
24 more

1 mention without citation

The crystal structures of human steroidogenic factor-1 and liver receptor homologue-1.
Wang et al. (2005)