1zgy

X-ray diffraction
1.8Å resolution

Structural and Biochemical Basis for Selective Repression of the Orphan Nuclear Receptor LRH-1 by SHP

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-153370 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Peroxisome proliferator-activated receptor gamma Chain: A
Molecule details ›
Chain: A
Length: 272 amino acids
Theoretical weight: 31.09 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P37231 (Residues: 234-505; Coverage: 54%)
Gene names: NR1C3, PPARG
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
Nuclear receptor subfamily 0 group B member 2 Chain: B
Molecule details ›
Chain: B
Length: 17 amino acids
Theoretical weight: 1.85 KDa
Source organism: Rattus norvegicus
UniProt:
  • Canonical: P97947 (Residues: 115-131; Coverage: 7%)
Gene names: Nr0b2, Shp

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 32-ID
Spacegroup: C2
Unit cell:
a: 102.602Å b: 54.493Å c: 66.497Å
α: 90° β: 97.5° γ: 90°
R-values:
R R work R free
0.231 0.231 0.258