› 1zjd

X-ray diffraction
2.6Å resolution

Crystal Structure of the Catalytic Domain of Coagulation Factor XI in Complex with Kunitz Protease Inhibitor Domain of Protease Nexin II

Released:
DOI: 10.2210/pdb1zjd/pdb
PDB entry 1zjd coloured by chain, front view.
PDB entry 1zjd coloured by chain, side view.
PDB entry 1zjd coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and mutational analyses of the molecular interactions between the catalytic domain of factor XIa and the Kunitz protease inhibitor domain of protease nexin 2.
Navaneetham D, Jin L, Pandey P, Strickler JE, Babine RE, Abdel-Meguid SS, Walsh PN
J Biol Chem 280 36165-75 (2005)
PMID: 16085935

Function and Biology Details

Reaction catalysed: 
Selective cleavage of Arg-|-Ala and Arg-|-Val bonds in factor IX to form factor IXa.
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137281 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Coagulation factor XIa light chain Chain: A
Molecule details ›
Chain: A
Length: 237 amino acids
Theoretical weight: 26.71 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P03951 (Residues: 388-624; Coverage: 39%)
Gene name: F11
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Soluble APP-beta Chain: B
Molecule details ›
Chain: B
Length: 57 amino acids
Theoretical weight: 6.28 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P05067 (Residues: 289-345; Coverage: 8%)
Gene names: A4, AD1, APP
Sequence domains: Kunitz/Bovine pancreatic trypsin inhibitor domain
Structure domains: Pancreatic trypsin inhibitor Kunitz domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: P3221
Unit cell:
a: 92.791Å b: 92.791Å c: 107.014Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.216 0.216 0.255
Expression system: Komagataella pastoris

Quick links

Citations

7 review citations

Structure and function of factor XI.
Emsley et al. (2010)
6 more

18 mentions without citation

Insights into the physiological function of the β-amyloid precursor protein: beyond Alzheimer's disease.
Dawkins et al. (2014)
17 more