› 1zmz

Solution NMR

Solution structure of the N-terminal domain (M1-S98) of human centrin 2

Released:
DOI: 10.2210/pdb1zmz/pdb
PDB entry 1zmz coloured by chain, ensemble of 20 models, front view.
PDB entry 1zmz coloured by chain, ensemble of 20 models, side view.
PDB entry 1zmz coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
The N-terminal domain of human centrin 2 has a closed structure, binds calcium with a very low affinity, and plays a role in the protein self-assembly.
Yang A, Miron S, Duchambon P, Assairi L, Blouquit Y, Craescu CT
Biochemistry 45 880-9 (2006)
PMID: 16411764

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154328 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Centrin-2 Chain: A
Molecule details ›
Chain: A
Length: 98 amino acids
Theoretical weight: 11.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P41208 (Residues: 1-98; Coverage: 57%)
Gene names: CALT, CEN2, CETN2
Sequence domains: EF-hand domain pair
Structure domains: EF-hand

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: molecular dynamics
Expression system: Escherichia coli

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Citations

8 review citations

Centrins in retinal photoreceptor cells: regulators in the connecting cilium.
Trojan et al. (2008)
7 more

3 mentions without citation

Calcium-induced conformational changes in the regulatory domain of the human mitochondrial ATP-Mg/Pi carrier.
Harborne et al. (2015)
2 more