› 1znj

X-ray diffraction
2Å resolution

INSULIN, MONOCLINIC CRYSTAL FORM

Released:
DOI: 10.2210/pdb1znj/pdb
PDB entry 1znj coloured by chain, front view.
PDB entry 1znj coloured by chain, side view.
PDB entry 1znj coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Turkenburg MGW, Whittingham JL, Turkenburg JP, Dodson GG, Derewenda U, Smith GD, Dodson EJ, Derewenda ZS, Xiao B

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero dodecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134235 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Insulin A chain Chains: A, C, E, G, I, K
Molecule details ›
Chains: A, C, E, G, I, K
Length: 21 amino acids
Theoretical weight: 2.38 KDa
Source organism: Homo sapiens
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: P01308 (Residues: 90-110; Coverage: 24%)
Gene name: INS
Insulin B chain Chains: B, D, F, H, J, L
Molecule details ›
Chains: B, D, F, H, J, L
Length: 30 amino acids
Theoretical weight: 3.43 KDa
Source organism: Homo sapiens
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: P01308 (Residues: 25-54; Coverage: 35%)
Gene name: INS
Sequence domains: Insulin/IGF/Relaxin family

Ligands and Environments

3 bound ligands:
Ligand IPH 7 x IPH
Ligand ZN 2 x ZN
Ligand CL 2 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH2R
Spacegroup: P21
Unit cell:
a: 61.23Å b: 61.65Å c: 48.05Å
α: 90° β: 110.5° γ: 90°
R-values:
R R work R free
0.178 0.178 not available
Expression system: Saccharomyces cerevisiae

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