› 1zr3

X-ray diffraction
1.66Å resolution

Crystal structure of the macro-domain of human core histone variant macroH2A1.1 (form B)

Released:
DOI: 10.2210/pdb1zr3/pdb
PDB entry 1zr3 coloured by chain, front view.
PDB entry 1zr3 coloured by chain, side view.
PDB entry 1zr3 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Getting a grip on O-acetyl-ADP-ribose.
Hoff KG, Wolberger C
Nat Struct Mol Biol 12 560-1 (2005)
PMID: 15999106

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130917 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Core histone macro-H2A.1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 211 amino acids
Theoretical weight: 22.27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O75367 (Residues: 162-369; Coverage: 56%)
Gene names: H2AFY, MACROH2A1
Sequence domains: Macro domain
Structure domains: Leucine Aminopeptidase, subunit E, domain 1

Ligands and Environments

1 bound ligand:
Ligand MES 1 x MES
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P212121
Unit cell:
a: 80.9Å b: 89.2Å c: 92.73Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.19 0.188 0.232
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

6 review citations

Nuclear ADP-ribosylation reactions in mammalian cells: where are we today and where are we going?
Hassa et al. (2006)
5 more

9 mentions without citation

The SARS-unique domain (SUD) of SARS coronavirus contains two macrodomains that bind G-quadruplexes.
Tan et al. (2009)
8 more