› 1zr9

Solution NMR

Solution Structure of a Human C2H2-type Zinc Finger Protein

Released:
DOI: 10.2210/pdb1zr9/pdb
PDB entry 1zr9 coloured by chain, ensemble of 20 models, front view.
PDB entry 1zr9 coloured by chain, ensemble of 20 models, side view.
PDB entry 1zr9 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
The solution structure of ZNF593 from Homo sapiens reveals a zinc finger in a predominantly unstructured protein.
Hayes PL, Lytle BL, Volkman BF, Peterson FC
Protein Sci 17 571-6 (2008)
PMID: 18287285

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126317 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Zinc finger protein 593 Chain: A
Molecule details ›
Chain: A
Length: 124 amino acids
Theoretical weight: 14.19 KDa
Source organism: Homo sapiens
Expression system: CELL-FREE SYNTHESIS
UniProt:
  • Canonical: O00488 (Residues: 20-134; Coverage: 86%)
Gene names: ZNF593, ZT86
Sequence domains: Zinc-finger double-stranded RNA-binding
Structure domains: Classic Zinc Finger

Ligands and Environments

1 bound ligand:
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: Automated methods were used for backbone chemical shift assignment and iterative NOE refinement. Final structures were obtained by molecular dynamics in explicit solvent.
Expression system: CELL-FREE SYNTHESIS

Quick links

Citations

2 review citations

Bioinformatic analyses and conceptual synthesis of evidence linking ZNF804A to risk for schizophrenia and bipolar disorder.
Hess et al. (2015)
1 more

6 mentions without citation

The conserved Bud20 zinc finger protein is a new component of the ribosomal 60S subunit export machinery.
Bassler et al. (2012)
5 more