› 1zsh

X-ray diffraction
2.9Å resolution

Crystal structure of bovine arrestin-2 in complex with inositol hexakisphosphate (IP6)

Released:
DOI: 10.2210/pdb1zsh/pdb
PDB entry 1zsh coloured by chain, front view.
PDB entry 1zsh coloured by chain, side view.
PDB entry 1zsh coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
Nonvisual arrestin oligomerization and cellular localization are regulated by inositol hexakisphosphate binding.
Milano SK, Kim YM, Stefano FP, Benovic JL, Brenner C
J Biol Chem 281 9812-23 (2006)
PMID: 16439357

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148193 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Beta-arrestin-1 Chain: A
Molecule details ›
Chain: A
Length: 418 amino acids
Theoretical weight: 47.2 KDa
Source organism: Bos taurus
Expression system: Escherichia coli
UniProt:
  • Canonical: P17870 (Residues: 1-418; Coverage: 100%)
Gene name: ARRB1
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand MG 1 x MG
Ligand IHP 1 x IHP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: P3221
Unit cell:
a: 78.88Å b: 78.88Å c: 158.38Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.25 0.25 0.26
Expression system: Escherichia coli

Quick links

Citations

33 review citations

Beta-arrestins and cell signaling.
DeWire et al. (2007)
32 more

21 mentions without citation

The Diverse Roles of Arrestin Scaffolds in G Protein-Coupled Receptor Signaling.
Peterson et al. (2017)
20 more