› 1zvm

X-ray diffraction
2.2Å resolution

Crystal structure of human CD38: cyclic-ADP-ribosyl synthetase/NAD+ glycohydrolase

Released:
DOI: 10.2210/pdb1zvm/pdb
PDB entry 1zvm coloured by chain, front view.
PDB entry 1zvm coloured by chain, side view.
PDB entry 1zvm coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Shi W, Yang T, Almo SC, Schramm VL, Sauve A

Function and Biology Details

Reactions catalysed: 
(1a) NADP(+) = 2'-phospho-cyclic ADP-ribose + nicotinamide
(1a) NAD(+) = cyclic ADP-ribose + nicotinamide
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-151306 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 256 amino acids
Theoretical weight: 29.68 KDa
Source organism: Homo sapiens
Expression system: Pichia
UniProt:
  • Canonical: P28907 (Residues: 45-300; Coverage: 85%)
Gene name: CD38
Sequence domains: ADP-ribosyl cyclase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand SO4 8 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X9B
Spacegroup: P2221
Unit cell:
a: 114.439Å b: 115.704Å c: 98.441Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.228 0.228 0.27
Expression system: Pichia

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