2a0z

X-ray diffraction
2.4Å resolution

The molecular structure of toll-like receptor 3 ligand binding domain

Released:
Source organism: Homo sapiens
Primary publication:
The molecular structure of the Toll-like receptor 3 ligand-binding domain.
Proc Natl Acad Sci U S A 102 10976-80 (2005)
PMID: 16043704

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127471 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (6 distinct):
Toll-like receptor 3 Chain: A
Molecule details ›
Chain: A
Length: 705 amino acids
Theoretical weight: 80.32 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: O15455 (Residues: 22-703, 704-709, 710-711; Coverage: 78%)
Gene name: TLR3
Sequence domains:
Structure domains: Ribonuclease Inhibitor

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer : NEW Components: NAG, FUC
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer : NEW Components: NAG, NDG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: C2221
Unit cell:
a: 141.603Å b: 160.795Å c: 122.543Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.206 0.206 0.232
Expression system: Trichoplusia ni