Function and Biology Details
Reaction catalysed:
Exonucleolytic cleavage of poly(A) to 5'-AMP
Biochemical function:
Biological process:
- not assigned
Cellular component:
- not assigned
Structure analysis Details
Assembly composition:
hetero tetramer (preferred)
Assembly name:
Poly(A)-specific ribonuclease PARN and RNA (preferred)
PDBe Complex ID:
PDB-CPX-131935 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct RNA molecule
1 distinct RNA molecule
Macromolecules (2 distinct):
Poly(A)-specific ribonuclease PARN
Molecule details ›
Chains: A, B
Length: 430 amino acids
Theoretical weight: 49.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: CAF1 family ribonuclease
Structure domains: Ribonuclease H-like superfamily/Ribonuclease H
Length: 430 amino acids
Theoretical weight: 49.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
O95453 (Residues: 1-430; Coverage: 67%)
Sequence domains: CAF1 family ribonuclease
Structure domains: Ribonuclease H-like superfamily/Ribonuclease H
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
ESRF BEAMLINE ID29
Spacegroup:
P212121
Expression systems:
- Escherichia coli
- Not provided
