› 2a24

Solution NMR

HADDOCK Structure of HIF-2a/ARNT PAS-B Heterodimer

Released:
DOI: 10.2210/pdb2a24/pdb
PDB entry 2a24 coloured by chain, ensemble of 20 models, front view.
PDB entry 2a24 coloured by chain, ensemble of 20 models, side view.
PDB entry 2a24 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of ARNT PAS-B dimerization: use of a common beta-sheet interface for hetero- and homodimerization.
Card PB, Erbel PJ, Gardner KH
J Mol Biol 353 664-77 (2005)
PMID: 16181639

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151026 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Endothelial PAS domain-containing protein 1 Chain: A
Molecule details ›
Chain: A
Length: 107 amino acids
Theoretical weight: 12.49 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q99814 (Residues: 242-348; Coverage: 12%)
Gene names: BHLHE73, EPAS1, HIF2A, MOP2, PASD2
Sequence domains: PAS domain
Structure domains: PAS domain
Aryl hydrocarbon receptor nuclear translocator Chain: B
Molecule details ›
Chain: B
Length: 108 amino acids
Theoretical weight: 12.82 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P27540 (Residues: 358-465; Coverage: 14%)
Gene names: ARNT, BHLHE2
Sequence domains: PAS domain
Structure domains: PAS domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing

Quick links

Citations

19 review citations

Theory, practice, and applications of paramagnetic relaxation enhancement for the characterization of transient low-population states of biological macromolecules and their complexes.
Clore et al. (2009)
18 more

6 mentions without citation

Circadian oscillator proteins across the kingdoms of life: structural aspects.
Saini et al. (2019)
5 more