› 2a3j

Solution NMR

Structure of URNdesign, a complete computational redesign of human U1A protein

Released:
DOI: 10.2210/pdb2a3j/pdb
PDB entry 2a3j coloured by chain, ensemble of 20 models, front view.
PDB entry 2a3j coloured by chain, ensemble of 20 models, side view.
PDB entry 2a3j coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
High-resolution structural validation of the computational redesign of human U1A protein.
Dobson N, Dantas G, Baker D, Varani G
Structure 14 847-56 (2006)
PMID: 16698546

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140455 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
U1 small nuclear ribonucleoprotein A Chain: A
Molecule details ›
Chain: A
Length: 127 amino acids
Theoretical weight: 13.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P09012 (Residues: 4-96; Coverage: 33%)
Gene name: SNRPA
Sequence domains: RNA recognition motif
Structure domains: Alpha-Beta Plaits

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

4 review citations

Sequence-specific binding of single-stranded RNA: is there a code for recognition?
Auweter et al. (2006)
3 more

2 mentions without citation

Energy functions in de novo protein design: current challenges and future prospects.
Li et al. (2013)
1 more