› 2a4j

Solution NMR

Solution structure of the C-terminal domain (T94-Y172) of the human centrin 2 in complex with a 17 residues peptide (P1-XPC) from xeroderma pigmentosum group C protein

Released:
DOI: 10.2210/pdb2a4j/pdb
PDB entry 2a4j coloured by chain, ensemble of 20 models, front view.
PDB entry 2a4j coloured by chain, ensemble of 20 models, side view.
PDB entry 2a4j coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Flexibility and plasticity of human centrin 2 binding to the xeroderma pigmentosum group C protein (XPC) from nuclear excision repair.
Yang A, Miron S, Mouawad L, Duchambon P, Blouquit Y, Craescu CT
Biochemistry 45 3653-63 (2006)
PMID: 16533048

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154329 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Centrin-2 Chain: A
Molecule details ›
Chain: A
Length: 79 amino acids
Theoretical weight: 9.23 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P41208 (Residues: 94-172; Coverage: 46%)
Gene names: CALT, CEN2, CETN2
Sequence domains: EF-hand domain pair
Structure domains: EF-hand
DNA repair protein complementing XP-C cells Chain: B
Molecule details ›
Chain: B
Length: 17 amino acids
Theoretical weight: 2.11 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q01831 (Residues: 847-863; Coverage: 2%)
Gene names: XPC, XPCC

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

Quick links

Citations

4 review citations

Centrins in retinal photoreceptor cells: regulators in the connecting cilium.
Trojan et al. (2008)
3 more

3 mentions without citation

DNA repair gets physical: mapping an XPA-binding site on ERCC1.
Croteau et al. (2008)
2 more