› 2a6d

X-ray diffraction
2.9Å resolution

Crystal structure analysis of the anti-arsonate germline antibody 36-65 in complex with a phage display derived dodecapeptide RLLIADPPSPRE

Released:
DOI: 10.2210/pdb2a6d/pdb
PDB entry 2a6d coloured by chain, front view.
PDB entry 2a6d coloured by chain, side view.
PDB entry 2a6d coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Differential epitope positioning within the germline antibody paratope enhances promiscuity in the primary immune response.
Sethi DK, Agarwal A, Manivel V, Rao KV, Salunke DM
Immunity 24 429-38 (2006)
PMID: 16618601

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
hetero dimer
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-211590 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Germline antibody 36-65 Fab light chain Chains: A, L
Molecule details ›
Chains: A, L
Length: 214 amino acids
Theoretical weight: 23.71 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins
Germline antibody 36-65 Fab Heavy chain Chains: B, H
Molecule details ›
Chains: B, H
Length: 222 amino acids
Theoretical weight: 23.94 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins
Dodecapeptide, RLLIADPPSPRE Chain: P
Molecule details ›
Chain: P
Length: 12 amino acids
Theoretical weight: 1.37 KDa

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P21
Unit cell:
a: 53.302Å b: 145.67Å c: 71.347Å
α: 90° β: 104.43° γ: 90°
R-values:
R R work R free
0.232 0.23 0.264

Quick links

Citations

15 review citations

Protein promiscuity and its implications for biotechnology.
Nobeli et al. (2009)
14 more

4 mentions without citation

Detect, correct, retract: How to manage incorrect structural models.
Wlodawer et al. (2018)
3 more